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By taking certain antidepressant in early postoperative period,which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.
  • Drug: Duloxetine Hydrochloride
    The treatment group will receive duloxetine 60mg/24h to 8 weeks after operation
    • Cymbalta
Ages eligible for Study
51 Years to 85 Years
Genders eligible for Study
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Inclusion Criteria:
  • No extra articular malformations are diagnosed and accord with Kellgren-Lawrence criteria
  • Primary TKA surgery,Varus is smaller than 20°
  • Always there is no history of mental illness, no history of relevant medicine
  • Be able to read and understand Chinese, with good communication skills
  • Voluntary participation in this clinical study
Exclusion Criteria:
  • Previous history of mental and psychological illness
  • With severe diseases in respiratory system, circulatory system or digestive system
  • Allergic to duloxetine and celecoxib
In this study, the investigators are going to investigate the efficacy of Duloxetine on pain, physical function, mental health and quality of life in patients underwent TKAs.

The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to 8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used to evaluate the two groups before and after operation for 4 and 8 weeks.

1 locations

China (1)
  • Dalian municipal central hospital
    Not specified
    Dalian, Liaoning, China, 116000
active not recruiting
Ⅰ, Ⅱ
31 December, 2016
11 April, 2017
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