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Risk Factors for the Development of Diabetes Mellitus After Distal Pancreatectomy (NCT03030209)

Glucose homeostasis changes after distal pancreatectomy are not well understood. This study aim to identify the incidence of and risk factors for, a change in glucose homeostasis in patients who underwent distal pancreatic resection.
  • Procedure: Distal pancreatectomy
    Distal pancreatectomy with or without splenectomy using minimal invasive or open approach
    Ages eligible for Study
    Genders eligible for Study
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • Patients undergoing distal pancreatectomy
    Exclusion Criteria:
    • Patients undergoing pancreaticoduodenectomy, middle pancreatectomy and enucleation
    • Patients with preoperative DM
    • Patients with functioning insulinoma and multiple endocrine neoplasia type 1
    The development of sophisticated surgical procedures, improved postoperative care, and the capacity for early diagnosis of disease, have prolonged life expectancy after pancreatic resection. For these patients, the endocrine function of the pancreas is a critical factor that influences quality of life. In this study, the investigators recruit patients who underwent distal pancreatectomy in Peking Union Medical College Hospital within the last 10 years. Demographic characteristics, operative parameters and short-term postoperative outcomes were collected in a prospective database maintained by the Pancreatic Surgical Centre, Peking Union Medical College Hospital. These patients are followed up regularly by outpatient visiting or telephone for long-term outcomes. The primary outcome of this study is new-onset diabetes mellitus; second outcomes include impaired fasting glucose, impaired glucose tolerance, exocrine insufficiency and disease recurrence. This study aim to determine the cumulative rates of endocrine insufficiency, and identify risk factors for DM development in a large cohort of patients undergoing distal pancreatectomy.

    1 locations

    China (1)
    • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
      Beijing, China, 100730
    31 December, 1999
    22 January, 2017
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