The purpose of the study to evaluate the feasibility of using low dose propranolol for people
Drug: Propranolol 1
Drug: Propranolol 2
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT03029845
Ages eligible for Study
18 Years to 65 Years
Genders eligible for Study
Accepts Healthy Volunteers
Females with fibromyalgia (both meeting 1990 American College of Rheumatology (ACR) FMS criteria and 2010 ACR FMS criteria) age 18-65 with at least 1 year of symptoms and sedentary (exercising less than 120 min per week).
Pregnancy or planning to be pregnant in the next year
Having Asthma requiring medication treatment including inhaler
Type I diabetes or Type II diabetes requiring medical therapy that can lead to hypoglycemia
Having acute pain or neuropathic pain
Participation in exercise or psychological treatment studies in the past 2 years
Having known serious psychopathology: Psychosis, history of inpatient psychiatric admission in the past year, active suicidal intent, history of self-injurious behaviors in the past year, history of recreational IV drug use, substance abuse history in the past year)
Having known cardiovascular diseases (self-report, physician diagnosed)
Bradycardia (resting heartrate of less than 55 bpm)
Resting diastolic BP < 55 mmHG or systolic BP<100 mmHG
ECG showing prolonged PR interval > .2 sec
ECG showing irregular PR interval
ECG showing incongruence between P wave and QRS
Allergy or intolerance of beta blockers
Current use of the following drugs:
Monoamine oxidase inhibitors
Tricyclics: daily dose greater than 75mg amitriptyline or equivalent
Benzodiazepine: daily dose greater than 5mg diazepam or equivalent
Asthmatic medicine, including inhaler
Participants may be included after minimum of 4 weeks of physician prescribed termination of these drugs
All locations for NCT03029845
United States (1)
University of Utah
Salt Lake City, Utah, United States, 84132
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Tris trial is registered with FDA with number: NCT03029845. The sponsor of the trial is University of Utah and it is looking for 30 volunteers for the current phase.
Official trial title: Propranolol for Treating Fibromyalgia Pain: Pilot Study
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