The Sponsor is developing the study drug, AZD0284, for the potential treatment of Plaque
psoriasis. Psoriasis is a skin condition that causes red, flaky, crusty patches of skin
covered with silvery scales. It occurs when skin cells are replaced more quickly than usual.
The seriousness of psoriasis varies greatly from person to person. For some people it is a
minor irritation, but for others it can have a major impact on their quality of life. .
The purpose of the study is to determine how much of AZD0284 is taken up by the body. The
safety and tolerability of the drug will also be assessed. It is hoped that the study drug
will improve the management of psoriasis.