Pre diabetes (PD) is a term that refers to alterations in glucose homeostasis, including
impaired fasting glucose (IFG), Imparied glucose tolerance (IGT) or both, involving a higher
risk to develop type 2 diabetes mellitus (T2DM) in 10 years.
The efficacy of pharmacotherapy in the prevention of diabetes in adults with prediabetes has
been demonstrated, the first line of pharmacology treatment is metformin, on the other hand,
the traditional Chinese and Ayurverica medicine offer potential active substances for the
treatment of hyperglucemia like berberine.
Berberine is an extract with hypoglycemic effects in animal models as well as in clinical
trials in type 2 diabetes mellitus even compared to metformin, for this reason comparing it's
activity against metformin in prediabetes would provide impact information on a new
alternative treatment and compare with the standard pharmacological treatment.
The aim of the study evaluate the effect of administration of berberine versus metaformine on
glycemic control, insulin secretion and insulin sensitivity in patients with pre diabetes.
The investigators hypothesis is that the administration of berberine versus metformin
modifies glycemic control, insulin sensitivity and insulin secretion in patients with