The purpose of this study is to investigate the efficacy and safety of vedolizumab
intravenous (IV) dose optimization on mucosal healing compared with the standard vedolizumab
IV dosing regimen over a 30 week treatment period in subjects with moderately to severely
active ulcerative colitis (UC) and high vedolizumab clearance, based on a Week 5 predefined
serum vedolizumab concentration threshold less than (<) 50 microgram per milliliter
(microg/mL) and who are Week 6 non-responders based on partial Mayo score.