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The purpose

This study aimed to detect cell free DNA (cfDNA) in the cerebrospinal fluid and plasma, and to determine whether cfDNA can be used for concomitant diagnosis to improve the treatment efficacy and prognosis of patients with brain (meningeal) metastasis by monitoring tumor-related genetic mutations in cfDNA in the plasma and cerebrospinal fluid.
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Tris trial is registered with FDA with number: NCT03029065. The sponsor of the trial is Shandong Cancer Hospital and Institute and it is looking for 50 volunteers for the current phase.
Official trial title:
Detection of CSF Next Generation Sequencing in the Application of Brain Metastases From Lung Adenocarcinoma or Meningeal Metastasis