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You can access this
clinical trial
if you have
Multiple Sclerosis
and you are
between 18 and 65
years old
Phase
4
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
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The purpose

Twenty subjects (10 patients and 10 age-matched control volunteers) will be recruited for this study. MRI scans will take place on a 3T MRI Scanner (Skyra or Prisma, Siemens Medical Solutions) located at The NYU Center for Biomedical Imaging. MRI scans will consist of a 1-hour brain scan for both patients and controls. In the first 6 months of the study, investigators will develop and test a uMT-based APT imaging for brain tissue pH measurement and use a hypercapnia paradigm to validate the tissue pH changes between breathing room air and 5% CO2 (by increasing tissue acidity) inhalation. With implementation of hypercapnia MRI, pH-weighted imaging will be validated for its robustness and reproducibility.

Provided treatments

  • Drug: Gd-DTPA-ST
  • Drug: Control
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Locations near you

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Tris trial is registered with FDA with number: NCT03028675. The sponsor of the trial is New York University School of Medicine and it is looking for 20 volunteers for the current phase.
Official trial title:
pH-weighted MRI in Multiple Sclerosis: A Surrogate Marker of Tissue Metabolic Stress