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More info
You can access this
clinical trial
if you have
Multiple Sclerosis
and you are
between 18 and 65
years old
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
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The purpose

Twenty subjects (10 patients and 10 age-matched control volunteers) will be recruited for this study. MRI scans will take place on a 3T MRI Scanner (Skyra or Prisma, Siemens Medical Solutions) located at The NYU Center for Biomedical Imaging. MRI scans will consist of a 1-hour brain scan for both patients and controls. In the first 6 months of the study, investigators will develop and test a uMT-based APT imaging for brain tissue pH measurement and use a hypercapnia paradigm to validate the tissue pH changes between breathing room air and 5% CO2 (by increasing tissue acidity) inhalation. With implementation of hypercapnia MRI, pH-weighted imaging will be validated for its robustness and reproducibility.

Provided treatments

  • Drug: Gd-DTPA-ST
  • Drug: Control
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Locations near you

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Tris trial is registered with FDA with number: NCT03028675. The sponsor of the trial is New York University School of Medicine and it is looking for 20 volunteers for the current phase.
Official trial title:
pH-weighted MRI in Multiple Sclerosis: A Surrogate Marker of Tissue Metabolic Stress