Twenty subjects (10 patients and 10 age-matched control volunteers) will be recruited for
this study. MRI scans will take place on a 3T MRI Scanner (Skyra or Prisma, Siemens Medical
Solutions) located at The NYU Center for Biomedical Imaging. MRI scans will consist of a
1-hour brain scan for both patients and controls. In the first 6 months of the study,
investigators will develop and test a uMT-based APT imaging for brain tissue pH measurement
and use a hypercapnia paradigm to validate the tissue pH changes between breathing room air
and 5% CO2 (by increasing tissue acidity) inhalation. With implementation of hypercapnia MRI,
pH-weighted imaging will be validated for its robustness and reproducibility.