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Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Arthritis, Rheumatoid
and you are
over 20
years old
This is a medium phase trial determining
the safety and dosage of the new treatment, as well as its efficacy.
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The purpose

This is a randomized, double-blind, parallel group, 3 dosage level, placebo-controlled, Phase 1/2 study designed to evaluate the pharmacokinetics, safety, tolerability, and efficacy of the monoclonal antibody GSK3196165, in Japanese subjects with active moderate-severe rheumatoid arthritis (RA) despite treatment with methotrexate(MTX). The subjects will receive GSK3196165 in combination with methotrexate therapy for the 12 weeks of treatment period. Approximately 55 subjects will be screened to achieve 40 randomized subjects, so as to have approximately 10 subjects in each treatment group.

Provided treatments

  • Drug: GSK3196165 Dose 1
  • Drug: GSK3196165 Dose 2
  • Drug: GSK3196165 Dose 3
  • Drug: Methotrexate
  • Drug: Placebo
  • Drug: Folic acid

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03028467. The sponsor of the trial is GlaxoSmithKline and it is looking for 15 volunteers for the current phase.
Official trial title:
A Phase 1/2, Double-Blind, Placebo-Controlled Study of the Pharmacokinetics, Safety and Tolerability of GSK3196165 in Combination With Methotrexate Therapy, in Japanese Subjects With Active Moderate-Severe Rheumatoid Arthritis Despite Treatment With Methotrexate