Elderly Patients / Non-cardiac Surgery
Nanfang Hospital of Southern Medical University
To investigate whether limb remote ischemic preconditioning (LRIP) could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.
- Procedure: limb remote ischemic preconditioning(LRIP)LRIP consisted of three cycles of left upper limb ischemia induced by inflating a blood pressure cuff on the left upper arm to 200mmHg, with an intervening 5 minutes of reperfusion, during which time the cuff was deflated.
|Ages eligible for Study||65 Years and older|
|Genders eligible for Study||All|
|Accepts Healthy Volunteers||No|
- elderly patients received elective non-cardiac surgery with general anesthesia
- anticipated surgery time > 2 hours
- age < 65 years old
- Acute coronary syndrome or myocardial infraction within 3 months
- Chronic obstructive pulmonary emphysema
- Serious hepatic dysfunction (Child-Pugh class C)
- serious renal dysfunction (undergoing dialysis before surgery)
- Ejection fraction less than 40%
- Poor pulmonary function (PaO2 <60mmHg)
- Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis
- Inability to communicate in the preoperative period (coma, profound dementia, or language barrier)
- Brain injury or neurosurgery
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.The primary outcomes included the incidence of delirium in the first 7 days after surgery using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scale.The quality of recovery over a 6-month period was evaluated as well.Secondary endpoints included length of stay in the hospital after surgery (from day of surgery to hospital discharge), occurrence of non-delirium postoperative complications, and all-cause 6-month mortality.
31 January, 2017
18 January, 2017