The purpose of this study is to assess the influence of transcranial magnetic stimulation
(TMS) on speech performance in individuals with primary progressive apraxia of speech.
Device: Transcranial Magnetic Stimulation (TMS)
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Full eligibility criteria for NCT03028324
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Adults ages 18 and above who are able to consent
Diagnosis of primary progressive apraxia of speech based on neurological evaluation
Any uncontrolled medical condition expected to limit life expectancy or interfere with participation in the trial (i.e. unstable cancer, severe depression or anxiety by DSM-IV criteria)
Abnormal stress test, as determined by the treating physician (unless cardiology clearance provided)
Active substance abuse or alcohol dependence
Uncorrected vision or hearing deficits that would preclude administration of the cognitive measures
Unwilling or unable to provide written informed consent
History of fainting spells of unknown or undetermined etiology that might constitute seizures
History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
No medication is an absolute exclusion from TMS. Medications will be reviewed by the responsible MD and a decision about inclusion will be made based on the following:
The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
The published TMS guidelines review medications to be considered with TMS
Any metal in the brain, skull or elsewhere unless approved by the responsible MD
Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD
Substance abuse or dependence within the past six months
Absence of corticospinal functional integrity
All locations for NCT03028324
United States (1)
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
View full eligibility
Tris trial is registered with FDA with number: NCT03028324. The sponsor of the trial is University of Miami and it is looking for 4 volunteers for the current phase.
Official trial title: Investigating the Use of Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)
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