This trial is completed!
Search for a recruiting clinical trial for your condition
Your journey
1What's a trial
2Find
3Review
4Get in touch
More info
You can access this
clinical trial
if you have
Raynaud Phenomenon Due to Trauma, Raynaud Disease, System; Sclerosis, Lupus Erythematosus, Systemic, Dermatomyositis or Ultrasound Therapy; Complications
and you are
between 13 and 99
years old
0
This is an early phase trial to investigate
how or whether the drug affects your body.
Show me locations

The purpose

Objective: To compare the efficacy of topical 10% nifedipine versus 5% sildenafil in patients with secondary Raynaud's phenomenon (RP). Methods: A randomized, double-blind, placebo-controlled pilot study took place in 10 patients with secondary RP. Topical 10% nifedipine on one hand and 5% sildenafil on the other hand were applied. The thumbs didn't receive any cream and served as a control group. The primary outcome was the improvement of blood flow and vessel diameter of the digital arteries measured by high frequency color Doppler ultrasound before and 1 hour after treatment.

Provided treatments

  • Drug: 10% nifedipine cream
  • Drug: 5% sildenafil cream
Tris trial is registered with FDA with number: NCT03027674. The sponsor of the trial is Pontificia Universidad Catolica de Chile and it is looking for 10 volunteers for the current phase.
Official trial title:
"Color Doppler Ultrasound Comparison of Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud: A Randomized, Double-blind, Placebo-controlled Pilot Study"