The brain is separated from the rest of the blood stream by the blood-brain barrier. This is
like a filter that protects the brain. But is also a challenge when medicines need to get
into the brain. Researchers want to give the new drug LB100 to people before brain tumor
surgery. They will measure how much LB100 is in the blood and how much gets into the brain.
This may help with the use of LB100 to treat brain tumors in the future.
To see if LB100 can pass into the brain.
People at least 18 years old with a brain tumor that requires surgery
Participants will be screened with:
Tumor sample. This can be from a previous procedure.
Participants will have their brain surgery at the Clinical Center.
Participants will get a dose of the study drug through a plastic tube in a vein for 2 hours
Participants will have blood taken 7 times in the 8 hours after getting the study drug.
Tumor samples will be taken during surgery.
Participants will have a heart test after getting the study drug. Sticky pads on the skin
will measure electrical activity of the heart.
Two weeks after leaving the hospital, participants will have a follow-up visit. They will
have a physical exam and blood tests.
One month after surgery, they will be contacted in person or by phone to see how they are