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Your journey
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More info
You can access this
clinical trial
if you have
Depressive Disorder, Major
and you are
between 18 and 65
years old
The phase for this study is not defined.
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The purpose

The goals of this study are: 1) to investigate the efficacy of combining ketamine with intensive cognitive behavioral therapy (CBT) to sustain the antidepressant effects of ketamine; and 2) to determine ketamine's delayed effects on learning and memory, and to explore the relationship between any ketamine-induced changes in learning and memory and duration of antidepressant efficacy, with and without CBT augmentation. Subjects with a diagnosis of MDD who are treatment-resistant to at least 2 antidepressants and have chosen to pursue clinical ketamine treatment at Yale Psychiatric Hospital will be recruited for the study.

Provided treatments

  • Other: Cognitive behavioral therapy (CBT) and medication
  • Other: Psychoeducation and medication

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03027362. The sponsor of the trial is Yale University and it is looking for 28 volunteers for the current phase.
Official trial title:
Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depression: a Randomized Controlled Trial