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Background: Primary hyperparathyroidism (PHPT) is often overlooked and underdiagnosed. At present the diagnosis of PHPT remains challenging and is based on serum calcium (Ca) and PTH. As serum Ca and phosphorous (P) are inversely related in PHPT, the Ca/P ratio might be considered a good candidate tool in the diagnosis of PHPT. AIM: The aim of this study is to investigate the diagnostic value of the Ca/P ratio in the diagnosis of PHPT. Study design: Retrospective, observational, cross-sectional, case-control clinical trial will be carried out. Biochemical measurements will include PTH, Vitamin D, serum Ca, P, albumin, and creatinine.
  • Other: No intervention are provided
    Ages eligible for Study
    18 Years to 90 Years
    Genders eligible for Study
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • elevated parathormone serum levels
    • normal or elevated calcium serum levels
    Exclusion Criteria:
    • age younger than 18 years
    • renal and liver failure and insufficiency
    • active metabolic bone disease (such as Paget's disease of the bone, osteomalacia, rickets, etc)
    • any type of cancer
    • malnutrition, severe obesity (BMI > 40 kg/m2) and malabsorption
    • transplantation
    • sarcoidosis
    • endocrinological disorders such as hypercortisolism, diabetes insipidus, hyperthyroidism, pseudohypoparathyroidism
    • familial hypocalciuric hypercalcemia
    • hypophosphoremia sustained by genetic causes or secondary to other causes.

    1 locations

    Italy (1)
    • Azienda USL of Modena
      Not specified
      Modena, Italy, 41126
    31 December, 2010
    13 February, 2017
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