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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Crohn Disease or Mycobacterium Avium Subspecies Paratuberculosis
and you are
between 18 and 50
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

A phase I dose escalation study to assess the safety and immunogenicity of the candidate vaccines ChAdOx2 HAV and MVA HAV in healthy volunteers. Volunteers will be recruited and vaccinated in Oxford, England. All vaccinations will be administered intramuscularly. Three different doses of the ChAdOx2 HAV will be tested (5x10^9 vp, 2.5x10^10 vp and 5x10^10vp). MVA HAV will be assessed at 2 different doses (5x10^7 and 2x10^8 pfu) The total duration of the study will be 52 weeks from the day of enrolment for volunteers receiving ChAdOx2 HAV only, 12 weeks for volunteers receiving MVA HAV only and 20 weeks for volunteers receiving ChAdOx2 HAV and MVA HAV.

Provided treatments

  • Biological: ChAdOx2 HAV
  • Biological: MVA HAV

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03027193. The sponsor of the trial is University of Oxford and it is looking for 28 volunteers for the current phase.
Official trial title:
A Phase I Clinical Trial to Determine the Safety and Immunogenicity of the Candidate Mycobacterium Avium Subspecies Paratuberculosis (MAP) Vaccines ChAdOx2 HAV and MVA HAV in Healthy Adult Volunteers