It was aimed to evaluate the contributions of T-PRF treatment combined with open flap
debridement on biological markers in GCF and periodontal outcomes in chronic periodontitis
patients. 29 patients (58 sites) with chronic periodontitis were treated either with
autologous T-PRF with OFD or OFD alone. GCF growth factor levels and relative RANKL/OPG ratio
at baseline and 2, 4 and 6 weeks postoperatively were analyzed, and clinical parameters such
as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at
baseline and 9 months after surgery were compromised.