The purpose of this study is to assess the benefit of MR screening for asymptomatic head &
neck (or CNS) second primary cancers occurring in hereditary retinoblastoma patients
previously treated by external beam radiation therapy (EBRT).
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Locations near you
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Full eligibility criteria for NCT03026998
Ages eligible for Study
7 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
- Personal history of hereditary retinoblastoma (i.e., familial history of
retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma,
or identified germline RB1 mutation or 13q deletion)
- External beam radiation therapy (EBRT) used for retinoblastoma treatment
- Age at inclusion greater or equal to 7 years old.
- Time period between the end of EBRT and inclusion date of 5 years or more
- Written informed consent signed by patient (or legal representative)
- Personal history of non-familial unilateral unifocal retinoblastoma without RB1
- Personal history of second primary neoplasm occurring within radiation fields
- Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators
or other implanted electronic devices, intracranial ferro-magnetic clips) or
associated conditions preventing from MR examination (intraocular prostheses and
implants are not a contraindication for MRI; orthodontic metallic devices are not a
contraindication but might decrease the image quality and should be removed, if
- Patients unable to comply with follow-up study requirements, for any geographical,
social or psychological reason
All locations for NCT03026998
Paris, France, 75005
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View full eligibility
Tris trial is registered with FDA with number: NCT03026998. The sponsor of the trial is Institut Curie and it is looking for 167 volunteers for the current phase.
Official trial title: MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma
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