Objectives: To assess the predictive value of IUS in children with IBD.
Design: A prospective longitudinal cohort study.
Setting: Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's
Participants: Children 2 years to 17 years (up to 200 patients) who have been diagnosed with
either CD or UC.
Main outcome measures: The changes in bowel wall thickness, assessed by IUS, during 2-year
follow-up according to therapeutic regimen.
Secondary outcome measures: Correlation of sonographic measures to clinical disease indices,
serum inflammatory and other laboratory markers, fecal calprotectin, endoscopic and other
radiologic measures performed as part of routine care.