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clinical trial
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Oral Lichen Planus
Phase
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

Oral Lichen Planus (OLP) is an autoimmune, chronic inflammatory mucocutaneous disease characterized by pain and burning sensation. The major types of OLP are the following: reticular, atrophic, erosive-ulcerative, bullous and pigmentous form.Its etiology remains unclear. The presence of auto-cytotoxic T cell clones in the lesions suggests the role of autoimmunity. Numerous treatment options of OLP include topical and systemic agents depending on severity of lesions . Topical corticosteroids abide the mainstay of therapy,and are widely accepted as the primary treatment of choice.Hence this study is designed to evaluate and compare the clinical efficacy of topical Clobetasol 0.05% in orabase and Betamethasone 0.05% in orabase in combination with Clotrimazole 1% in the management of symptomatic Oral Lichen Planus.

Provided treatments

  • Drug: Betamethasone Dipropionate
  • Drug: Clobetasol Propionate
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Tris trial is registered with FDA with number: NCT03026478. The sponsor of the trial is Garlapati Komali and it is looking for 30 volunteers for the current phase.
Official trial title:
A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus