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More info
You can access this
clinical trial
if you have
Oral Lichen Planus or Oral Squamous Cell Carcinoma
and you are
between 30 and 70
years old
-
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa. Global protein profiling methods based on liquid chromatography coupled to mass spectrometry were used, with a special emphasis on evaluation of deregulated extracellular matrix molecules expression, as well as on analyses of insulin-like growtg factor 2 (IG2F) and insulin-like growth factor 2 receptor (IGFR2) expression in healthy mucosa, OLP and OSCC tissues by comparative semiquantitative immunohistochemistry. Mass spectrometry based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and accompanied histologically unaltered tissues, respectively) identified 55 extracellular matrix proteins. Twenty among identified proteins were common to all groups of samples. Statistically significant difference between final IGF2 and IGF2R IRS scores in favour to IGF2R may further corroborate the IG2FR antitumor role in OLP and OSCC where it acts as a negative regulator of IGF2 activity.

Provided treatments

  • Genetic: global proteomic profiling

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03026361. The sponsor of the trial is University of Zagreb and it is looking for 71 volunteers for the current phase.
Official trial title:
Molecular Mechanisms of Precancerous and Cancerous Lesions of the Oral Cavity