The purpose of this project is to study brain imaging of a substance called tau, which is
found in brains of persons with Alzheimer's disease, using the Tau binder, 18F-THK-5351, for
live imaging of tau in the brain. The main goal of this proposal is to study whether diabetes
status (type 2 diabetes [referred to as diabetes] and pre-diabetes, compared with normal
glucose tolerance [NGT]), is associated with increased tau accumulation in the brain, one of
the culprits of Alzheimer's disease, in a community-based group of middle aged
Caribbean-Hispanics with a mean age of 63 years. The investigators propose to conduct tau
positron emission tomography (PET) imaging in 30 middle aged Hispanics.