This pilot trial evaluates in vivo megestrol acetate (MA) modulation of steroidal receptors
in advanced breast cancer.
Drug: Megestrol Acetate 160Mg Tablet
Drug: Anastrozole 1Mg Tablet
Drug: Letrozole 2.5Mg Tablet
Drug: Exemestane 25 MG
Drug: Tamoxifen 20Mg Tablet
Drug: Fulvestrant 50Mg Solution for Injection
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Full eligibility criteria for NCT03024580
Ages eligible for Study
Genders eligible for Study
Accepts Healthy Volunteers
Metastatic breast cancer with ER and/or PR positive (primary tumor)
Metastatic site amenable to biopsy
Platelet count below 100,000 / mm3
Renal or hepatic impairment
All locations for NCT03024580
Hospital do Cancer III
Rio de Janeiro, Brazil, 20560120
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Tris trial is registered with FDA with number: NCT03024580. The sponsor of the trial is Instituto Nacional de Cancer, Brazil and it is looking for 20 volunteers for the current phase.
Official trial title: A Pilot Study Evaluating Megestrol Acetate Modulation in Advanced Breast Cancer With Positive Hormonal Receptor
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