Patients aged between 20 and 70 years, ASA physical status I-III, and scheduled for
laparoscopic cholecystectomy under general anaesthesia will be enrolled in the study.
Patients will be randomized to the preemptive group to receive an antiemetic regime 1h before
the start of surgery or to the intraoperative group to receive the same antiemetic drugs in
the same doses intraoperatively, 30 min before the end of surgery.
In the operating room standard monitoring and a standardized anesthetic technique will be
implemented in all patients. Nausea, vomiting, retching and PONV (cumulative) will be
recorded at PACU, at 4h, 8h and 24h postoperatively. Pain scores assessed by NRS (numerical
rating scale) will be recorded at the same time points. Also, when patients received fluids
and solid food by mouth will be recorded.