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You can access this
clinical trial
if you have
Alzheimer Disease or Benson's Disease
and you are
over 50
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

Recently revised Alzheimer Disease (AD) diagnostic1described nonamnestic presentations: 1/ language presentation (logopenic progressive aphasia) 2/ visuospatial presentation (posterior cortical atrophy or PCA) and 3/ executive dysfunction. AD pathological changes may precede the clinical diagnosis of dementia of AD type for a while2. Biomarkers have been developed: biomarkers of brain amyloid-beta (Aß) (CerebroSpinal Fluid CSF concentration ßamyloid, molecular imaging with amyloid targeted PET ligands), biomarkers of neural degeneration (MRI hippocampal volume, regional metabolism as assessed by PET with [18F]-FDG) and may be used to made early detection of the neuropathology associated with AD Even if CSF biomarkers (tau, p-tau and β amyloïd are interesting to improve diagnosis of AD, they cannot provide topographic information. PET tau imaging seems to be promise to evaluate quantitative and spatial assessment of tau lesions both in AD and fronto-temporal lobar dementia. The hypothesis of the research is that it exists a different regional pattern of tracer retention across brain regions according to clinical symptoms : temporal for logopenic aphasia and occipital for posterior cortical atrophy.

Provided treatments

  • Drug: [18F]T807 PET
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Locations near you

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Tris trial is registered with FDA with number: NCT03022968. The sponsor of the trial is University Hospital, Tours and it is looking for 24 volunteers for the current phase.
Official trial title:
Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD)