Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the
proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is
associated with increased mortality through its linkage to comorbidities including diabetes,
hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given
its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of
obesity and its consequences is one of the most important problems of our time.
In this proposed study, investigators will recruit subjects from a wide range of body mass
index (BMI), ethnicity and Diabetes risk to collect data and blood, stool and adipose tissue
samples in the San Francisco bay area.