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More info
You can access this
clinical trial
if you have
Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System, Glioblastoma or Anaplastic Astrocytoma
and you are
over 18
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

You are being asked to take part in this study because you have glioblastoma or anaplastic astrocytoma (AA) that has relapsed (come back) after treatment and the study doctor thinks that it is in your best interest to receive chemotherapy for the disease. Additionally, the study doctor thinks it may be in your best interest to also have a surgical procedure called laser interstitial thermal therapy (LITT). LITT is a minimally invasive (using small incisions) surgery method that uses lasers to destroy tumor cells. For the procedure, the study doctor uses the NeuroBlate system to perform LITT in combination with MRIs and software models to focus the lasers on affected brain cells. The goal of this clinical research study is to learn if the NeuroBlate system in combination with lomustine can help to control glioblastoma or anaplastic astrocytoma (AA) that has returned after treatment. The safety of the combination will also be studied. This is an investigational study. The NeuroBlate system is FDA approved and commercially available for different types of brain surgery. Lomustine is FDA approved and commercially available for the treatment of brain tumors. LITT using the NeuroBlate System in combination with lomustine for the treatment of glioblastoma is investigational. The study doctor can describe how the study drug and procedure are designed to work. Up to 34 participants will be enrolled in this study. All will take part at MD Anderson.

Provided treatments

  • Procedure: Laser Interstitial Thermal Therapy
  • Drug: Lomustine
  • Behavioral: Quality of Life Questionnaires
  • Device: The NeuroBlate System
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Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03022578. The sponsor of the trial is M.D. Anderson Cancer Center and it is looking for 34 volunteers for the current phase.
Official trial title:
Phase II Study of Laser Interstitial Thermal Therapy (LITT) in Recurrent Glioblastoma