You are being asked to take part in this study because you have glioblastoma or anaplastic
astrocytoma (AA) that has relapsed (come back) after treatment and the study doctor thinks
that it is in your best interest to receive chemotherapy for the disease. Additionally, the
study doctor thinks it may be in your best interest to also have a surgical procedure called
laser interstitial thermal therapy (LITT). LITT is a minimally invasive (using small
incisions) surgery method that uses lasers to destroy tumor cells.
For the procedure, the study doctor uses the NeuroBlate system to perform LITT in combination
with MRIs and software models to focus the lasers on affected brain cells.
The goal of this clinical research study is to learn if the NeuroBlate system in combination
with lomustine can help to control glioblastoma or anaplastic astrocytoma (AA) that has
returned after treatment. The safety of the combination will also be studied.
This is an investigational study. The NeuroBlate system is FDA approved and commercially
available for different types of brain surgery. Lomustine is FDA approved and commercially
available for the treatment of brain tumors. LITT using the NeuroBlate System in combination
with lomustine for the treatment of glioblastoma is investigational.
The study doctor can describe how the study drug and procedure are designed to work.
Up to 34 participants will be enrolled in this study. All will take part at MD Anderson.