Prospective observational study to compare sensitivity of 3T functional Magnetic Resonance
Imaging (3T fMRI) at diagnosing Parkinson's Disease (PD) against the benchmark DaTScan
diagnostic test and clinical diagnosis at follow up.
Other: Patient assessment
Radiation: Orbital X-Ray
Other: Magnetic Resonance Imaging (MRI)
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT03022357
Ages eligible for Study
21 Years to 90 Years
Genders eligible for Study
Accepts Healthy Volunteers
Ability to give informed consent
Age > 21 to < 90 years
Clinical symptoms suspicious for a diagnosis of Parkinson's disease but clinical uncertainty with regards to a definite diagnosis:
Clinical symptoms not meeting all of the required UK brain bank diagnostic criteria for the diagnosis of PD
Clinical features not typically associated with PD and therefore raising the possibility of a different type disorder/movement disorder
Referred for a DatScan as part of the NHS clinical diagnostic workup to investigate a suspicion for a parkinsonian movement disorder type disease or referred for a research DatScan as part of this study for the diagnostic workup to investigate a suspicion for a parkinsonian movement disorder type disease.
Participants with any known contraindication to MRI such as:
Intracranial aneurysm clips
Cardiac pacemakers and defibrillators
MR-incompatible metal implant or tattoo
Patients with a significant head tremor
Participants that are felt to be unfit for the MRI scan according to the judgement of medically qualified personnel, either on the research team, or the patient's clinical team. (eg. due to back pain, claustrophobia, acute sickness etc.) This includes patients with signs of impaired temperature regulation such as an extremely high fever.
(only for those planned for research DatScan) Participants in which a DatScan nuclear medical study can't be performed due to
Severe allergy to iodide compounds
Thyroid gland dysfunction
All locations for NCT03022357
United Kingdom (3)
Derby, Derbyshire, United Kingdom, DE22 3NE
not yet recruiting
London, United Kingdom, SW7 2AZ
not yet recruiting
University of Nottingham
Nottingham, United Kingdom, NG7 2RD
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View full eligibility
Tris trial is registered with FDA with number: NCT03022357. The sponsor of the trial is University of Nottingham and it is looking for 145 volunteers for the current phase.
Official trial title: Nigrosomal Iron Imaging in Parkinson's Disease
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