However, there is only very sparse information regarding the atherosclerotic burden and
cardiovascular biomarkers in the early stages of type-2 diabetes, as the vast majority of
studies have concerned diabetes populations with more than 5 years average diabetes age or
high-risk subgroups, who at inclusion already had atherosclerotic disease manifestations.
Consequently, this study aims on evaluating the occurrence of early-stage subclinical
atherosclerosis in newly diagnosed type-2 diabetes with special emphasis on coronary plaque
characteristics by modern imaging techniques. These findings will be compared to the
functional status of various peripheral arterial segments and biomarkers in the
cross-sectional part of this study. The 5-year follow-up study intends to describe
relationships between these selected measures for general atherosclerotic involvement and the
progression of the coronary atherosclerotic burden by contemporary techniques.