To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on
individualized fluid and cardiac output optimization on postoperative moderate and severe
complications in patients undergoing major abdominal surgery including visceral, urological,
and gynecological operations.
In the proposed study, hemodynamic therapy is tailored individually to each patient, based on
individual preload optimization by the functional parameter "pulse pressure variation (PPV)"
and based on an individually titrated goal of cardiac index. The proposed study therefore
further develops the concept of hemodynamic goal-directed therapy to individually set goals
and is designed to assess its impact on morbidity and mortality.