Patients must be informed of the investigational nature of this study and give written informed consent.
WHO Type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma.
Age >18 years.
Treatment with palliative intent.
Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer.
Pregnancy or lactation.
History of previous radiotherapy (except for non-melanomatous skin cancers outside intended RT treatment volume).
Prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes.
Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose
>1.5×ULN), and emotional disturbance.
All locations for NCT03020329
Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
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Tris trial is registered with FDA with number: NCT03020329. The sponsor of the trial is Sun Yat-sen University and it is looking for 37 volunteers for the current phase.
Official trial title: Phase II Study of TPF Induction Chemotherapy Followed by Concurrent Chemoradiotherapy in Young Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
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