Sedative and analgesic agents are widely used in the ICU. These agents can provide hypnotic
effect, pain alleviation, cooperation, and synchronizing ventilatory support. Prolonged use
of the agents can lead to withdrawal symptoms when the drugs are weaned.
Prior study showed the longer duration of sedative drugs, cumulative dose of medications and
younger age were the risk factors of withdrawal syndrome. Additional, some study showed the
sedation protocol can reduce the incidence of withdrawal syndrome. However, no worldwide
standardized sedative weaning protocol including our hospital. The objectives in this study
are to establish the sedative weaning protocol and to compare the protocol sedative weaning
with the usual care weaning.