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More info
You can access this
clinical trial
if you have
Estrogen Deficiency, Cardiovascular Disease (CVD) or Hypothalamic Amenorrhea
and you are
between 18 and 60
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

The purpose of this study is to determine whether low estrogen levels in young women with hypothalamic amenorrhea (premenopausal HypoE) is associated with risk factors for cardiovascular disease. For this study, the investigators will measuring vascular function and immune markers on: - young women with hypothalamic amenorrhea (>3 months of no menstrual cycle due to low estrogen) - young women with regular menstrual cycles not on hormone therapy. - recently menopausal women (<3 years from final menstrual period) not on hormone therapy. Premenopausal HypoE participants will then be randomized to use either an estrogen patch or a placebo patch (no active medicine) for 3 months, followed by estrogen or placebo patch plus progesterone or placebo pills for 2 additional weeks. The investigators are looking to see if estrogen improves vascular and immune function.

Provided treatments

  • Drug: 17beta Estradiol
  • Drug: Transdermal placebo patch
  • Drug: Progesterone
  • Drug: Placebo Pill
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Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03018366. The sponsor of the trial is Cedars-Sinai Medical Center and it is looking for 30 volunteers for the current phase.
Official trial title:
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women