The purpose of this study is to determine whether low estrogen levels in young women with
hypothalamic amenorrhea (premenopausal HypoE) is associated with risk factors for
For this study, the investigators will measuring vascular function and immune markers on:
- young women with hypothalamic amenorrhea (>3 months of no menstrual cycle due to low
- young women with regular menstrual cycles not on hormone therapy.
- recently menopausal women (<3 years from final menstrual period) not on hormone therapy.
Premenopausal HypoE participants will then be randomized to use either an estrogen patch or a
placebo patch (no active medicine) for 3 months, followed by estrogen or placebo patch plus
progesterone or placebo pills for 2 additional weeks. The investigators are looking to see if
estrogen improves vascular and immune function.