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Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma or Recurrent Primary Peritoneal Carcinoma
and you are
over 18
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

This phase I trial studies the side effects of genetically modified T cells and decitabine in treating patients with recurrent or refractory epithelial or non-epithelial ovarian, primary peritoneal, or fallopian tube cancer that has come back or has not responded to previous treatments. White blood cells called T cells are collected via a process called leukapheresis, genetically modified to recognize and attack tumor cells, then given back to the patient. Decitabine may induce and increase the amount of the target protein NY-ESO-1 available on the surface of tumor cells. Giving genetically modified T cells and decitabine may kill more tumor cells.

Provided treatments

  • Biological: Aldesleukin
  • Drug: Cyclophosphamide
  • Drug: Decitabine
  • Biological: Genetically Engineered NY-ESO-1-specific T Lymphocytes
  • Other: Laboratory Biomarker Analysis

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03017131. The sponsor of the trial is Roswell Park Cancer Institute and it is looking for 9 volunteers for the current phase.
Official trial title:
A Phase I Open Label Clinical Trial Evaluating the Safety and Efficacy of Adoptive Transfer of NY-ESO-1 TCR Engineered Autologous T Cells in Combination With Decitabine in Patients With Recurrent or Treatment Refractory Ovarian Cancer