Optimal understanding of ciprofloxacin pharmacokinetics in critically ill patients is lacking
resulting in large variation of achieved exposure and possible inadequate therapy. The
investigators hypothesize that drug dosing based on CKD-EPIcr-cys provides a useful method to
individualize and optimize therapy for ciprofloxacin and eventually improve outcome.
In a multi-centre, observational, open-label study the investigators aim to define : the
model for estimation of renal function that most accurately predicts ciprofloxacin clearance
in critically ill patients.