This study seeks to determine whether a smartphone application called CRADLE (ComputeR
Assisted Detection of LEukocoria) has the potential to improve the detection of leukocoria.
There will be no impact on participants' health outcome.
This study will be performed in two parts, each with a distinct cohort of patients.
Part 1 will assess the feasibility of various techniques/conditions for using CRADLE within
patients known to have leukocoria.
Part 2 will estimate the sensitivity and specificity of CRADLE to detect leukocoria (using
the techniques selected from information gathered in Part 1) as compared to an
ophthalmoscope, within patients referred to the clinic for suspected leukocoria.
- To determine the most effective usage of a camera phone application (CRADLE) to maximize
detection of leukocoria in patients with retinoblastoma, congenital cataracts, and
- To estimate the sensitivity and specificity of a camera phone application (CRADLE) in