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More info
You can access this
clinical trial
if you have
Endogenous and Esophageal Sensitivity
and you are
between 18 and 60
years old
-
The phase for this study is not defined.
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The purpose

The aim of this study was to investigate the effect of naloxone (IV or IM administration) and methylnaltrexone (subcutaneous administration) on esophageal sensitivity, in a group of healthy volunteers in order to evaluate the role of endogenous opiods in symptom perception in gastro-esophageal reflux disease. Esophageal sensitivity was assessed by using a multimodal esophageal stimulation protocol where sensitivity to thermal, mechanical, electrical and chemical stimulation was tested.

Provided treatments

  • Drug: Naloxone
  • Drug: Methylnaltrexone Bromide
  • Other: Placebo

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03014843. The sponsor of the trial is Universitaire Ziekenhuizen Leuven and it is looking for 12 volunteers for the current phase.
Official trial title:
The Effect of Naloxone and Mehtylnaltrexone on Esophageal Sensitivity in Healthy Volunteers: a Randomized, Double-blind, Placebo-controlled Study