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More info
You can access this
clinical trial
if you have
Endogenous and Esophageal Sensitivity
and you are
between 18 and 60
years old
The phase for this study is not defined.
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The purpose

The aim of this study was to investigate the effect of naloxone (IV or IM administration) and methylnaltrexone (subcutaneous administration) on esophageal sensitivity, in a group of healthy volunteers in order to evaluate the role of endogenous opiods in symptom perception in gastro-esophageal reflux disease. Esophageal sensitivity was assessed by using a multimodal esophageal stimulation protocol where sensitivity to thermal, mechanical, electrical and chemical stimulation was tested.

Provided treatments

  • Drug: Naloxone
  • Drug: Methylnaltrexone Bromide
  • Other: Placebo

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03014843. The sponsor of the trial is Universitaire Ziekenhuizen Leuven and it is looking for 12 volunteers for the current phase.
Official trial title:
The Effect of Naloxone and Mehtylnaltrexone on Esophageal Sensitivity in Healthy Volunteers: a Randomized, Double-blind, Placebo-controlled Study