The neural circuits in our brains require a layer of insulation in order to transmit signals
in a rapid and efficient fashion. This insulation is called White Matter and is comprised of
a specific type of brain cell called an oligodendrocytes. Damage to brain white matter occurs
following injury and in disorders like Multiple Sclerosis and results in sensory, motor, and
cognitive problems. Currently there are no effective medical therapies to promote brain
repair and reduce disability following damage to white matter. In this project, we hope to
change the situation by encouraging the brain itself to generate new oligodendrocytes and
thus new white matter. Our first step is to find measures sensitive to white matter growth.