Periodontitis is a major oral health problem which leads to the progressive destruction of
periodontal ligament and alveolar bone with pocket formation, recession or both. The ultimate
goal of periodontal therapy is to regenerate the lost periodontal tissue. The most common
form of regenerative periodontal therapy is the use of bone grafts which stimulate bone
formation by the processes of osteoinduction and osteoconduction.
Statins are a group of lipid lowering drugs which inhibit bone resorption by inhibition of
the enzyme HMG-CoA reductase. They also stimulate new bone formation by local stimulation of
BMP-2, a major bone growth regulatory factor. They also have anti-inflammatory and anti
Very few studies exist evaluating the beneficiary effects of grafts if combined with the
statins which might enhance the regeneration by bone grafts.
Hence, the present study was carried out in an attempt to comparatively evaluate clinically
and radiologically, the efficacy of atorvastatin gel as an adjunct to allograft in the
treatment of intrabony defects.