Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Disorder of Consciousness, Minimally Conscious State, Vegetative State or Cognitive Impairment
and you are
between 18 and 80
years old
This is a trial in the final phase before the treatment is released on the market.
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The purpose

Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of consciousness and functional communication in some minimally conscious state (MCS) patients, and in some vegetative state (VS) patients. However the optimal intensity of electrical current stimulation remains unknown. This study will test the effects of two intensities of tDCS stimulation (either 0.2mA or 2mA) applied on left dorso-lateral prefrontal cortex on both behavior, - assessed by the Coma Recovery Scale-Revised (CRS-R) scores -, as well as quantified EEG recorded during resting state (using algorithms previously designed and published by the investigators) and event-related potentials (using auditory paradigms we previously published) in severely brain damaged patients with disorders of consciousness (MCS, VS, and conscious but cognitively disabled patients) of various etiologies.

Provided treatments

  • Device: transcranial direct current stimulation (tDCS) / Comparison of current intensities
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Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT03007784. The sponsor of the trial is Groupe Hospitalier Pitie-Salpetriere and it is looking for 300 volunteers for the current phase.
Official trial title: