Limited treatments are available to improve consciousness in severely brain injured patients.
Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed
evidence of efficacy to increase level of consciousness and functional communication in some
minimally conscious state (MCS) patients, and in some vegetative state (VS) patients. However
the optimal intensity of electrical current stimulation remains unknown.
This study will test the effects of two intensities of tDCS stimulation (either 0.2mA or 2mA)
applied on left dorso-lateral prefrontal cortex on both behavior, - assessed by the Coma
Recovery Scale-Revised (CRS-R) scores -, as well as quantified EEG recorded during resting
state (using algorithms previously designed and published by the investigators) and
event-related potentials (using auditory paradigms we previously published) in severely brain
damaged patients with disorders of consciousness (MCS, VS, and conscious but cognitively
disabled patients) of various etiologies.