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More info
You can access this
clinical trial
if you have
Childhood Brain Tumor
and you are
between 4 and 18
years old
-
The phase for this study is not defined.
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The purpose

The investigators will focus on two cohorts of brain tumor patients aged, 4-18 years, to answer two critical questions: 1) Can the investigators acquire high quality data relevant to cognitive function during the peri-diagnostic period and, 2) can the investigators develop predictive models for cognitive outcomes using serial examination of functional imaging and cognitive function. Any patient with a newly diagnosed brain tumor aged 4-18 will be eligible for enrollment in cohort 1. Only patients with previously diagnosed tumors of the posterior fossa will be eligible for cohort 2. The rationale for of the focus on these patients is that first, the posterior fossa is the most common location for pediatric brain tumors and therefore this focus will impact the largest segment of this patient population. Second, three tumors commonly occur here, medulloblastoma, ependymoma and pilocytic astrocytoma. These are treated with surgery, radiation and chemotherapy (medulloblastoma), surgery and radiation therapy (ependymoma) or surgery only (pilocytic astrocytoma). Thus, this focus will provide a platform to analyze the impact that different tumor types and different standard treatments have on cognitive dysfunction. Finally, the fact that all subjects will have tumors of the same brain region will control for the effect that tumor location will have on cognitive testing and rsfcMRI. Here, repeated evaluations on and off therapy will provide the necessary data points to establish trajectories of cognitive development and recovery in this population.

Provided treatments

  • Other: Neurocognitive testing
  • Device: rsfcMRI
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Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02914067. The sponsor of the trial is Washington University School of Medicine and it is looking for 150 volunteers for the current phase.
Official trial title:
Cognitive Biomarkers in Pediatric Brain Tumor Patients