The intrinsic asthma (atopic or not) is a particular phenotype marked by an early later
symptoms, increased severity, sensitivity associated with nonsteroidal anti-inflammatory
drugs (NSAIDs), a sinonasal polyposis and eosinophilia.
Unlike allergic asthma, this form does not today demonstrated its genetic character. However,
the existence of familial forms of asthma in this region Pays de La Loire led us to
hypothesize the existence of genetic variations can explain some familial forms of non-atopic
asthma. Corresponding genes may be relevant to understanding the pathophysiological pathways
involved in the more common sporadic forms.
The investigators propose a study combining genetic linkage analysis and complete sequencing
exomes to identify one or more genetic abnormalities associated with non-atopic asthma. The
clinical stage essential for mutation identification is to identify and recruit large
families with members affected by non-atopic asthma and ensure accurate phenotyping of all
individuals recruited over several generations.
The aim of this study is to create a cohort of families who have more members within them
non-atopic asthma. A high genetic combined exome sequencing throughput analysis in a family
linkage study will then reveal the presence or absence of genetic variations associated with