Researchers want to test a procedure called deep brain simulation (DBS) to treat focal hand
dystonia (FHD). A device called a neurostimulator is placed in the chest. It is attached to
wires placed in brain areas that affect movement. Stimulating these areas can help block
nerve signals that cause abnormal movements.
To test DBS as treatment for FHD. To learn about brain and nerve cell function in people with
People ages 18 and older with severe FHD who have tried botulinum toxin treatment at least
Participation lasts 5 years.
Participants will be screened with:
Videotape of their dystonia
Blood, urine, and heart tests
Brain MRI scan
Neuropsychological tests: answering questions, doing simple actions, and taking memory and
Hand movement tests
Participants will have surgery: A frame fixes their head to the operating table. A small hole
is made in the skull. Wires are inserted to record brain activity and stimulate the brain
while they do simple tasks. The wires are removed and the DBS electrode is inserted into the
hole. The neurostimulator is placed under the skin of the chest, with wires running to the
electrode in the brain. They will have CT and MRI scans during surgery.
Participants will recover in the hospital for about 1 week.
The neurostimulator will be turned on 1 4 weeks after discharge. Participants will have
regular visits until the study ends. Visits include:
Checking symptoms and side effects
Movement, thinking, and memory tests
If the neurostimulator s battery runs out, participants will have surgery to replace it.