Angina is the most common symptom of coronary heart disease among women but unlike men most
women do not have stenosis of the coronary arteries. In a large proportion of these women,
coronary microvascular dysfunction (CMD) is thought to be the cause of angina. However, CMD
is also demonstrable in the asymptomatic population, and may merely be an innocent bystander
related to the presence of cardiovascular risk factors rather than a cause of angina
The aim of this study is to determine whether comprehensive intervention is feasible and
results in improvement in both angina and microvascular function in these patients.