Introduction: Acute encephalitis (AE) is a severe neurological disorder associated with
significant morbidity and mortality. Approximately 50% of patients with AE require ICU
admission because of coma, seizures or acute respiratory failure. Determinants of
neurological prognosis in these patients are not known.
Main objective: To identify determinants of outcome in adult patients admitted to the ICU;
Secondary objectives: a) To study the impact of diagnostic studies (Brain MRI, CSF analysis,
EEG) on neurologic outcome; b) to describe the epidemiology of patients admitted to the ICU
with AE; c) to study the impact of early appropriate therapy on neurologic outcomes; d) to
describe morbidity and mortality associated with AE at 90 days and 1 year following
Methods: prospective observational multicenter study in French ICUs. All patients admitted to
the ICU for probable or confirmed AE (2013 IDSA criteria)with a Glasgow coma scale score < or
=to 13 will be eligible for inclusion. Factors associated with a poor prognosis at 90 days
will be identified by multivariable logistic regression analysis.
Duration of study: 30 months (recruitment 18 months, follow-up 12 months).
Patients: 300 patients
- Primary endpoint: The primary endpoint is the modified Rankin scale score 90 days
following onset of abnormal status (GCS < or =13). This score will be determined by
contacting the patient. A poor outcome will be defined as a mRS >2 at 90 days.
- Secondary endpoints: a) neurological findings within 7 days following onset of altered
mental status; b) abnormal findings on diagnostic studies (MRI, EEG, CSF analysis)
within7 days following onset of altered mental status; c) Time between onset of altered
mental status and completion of diagnostic studies; d)Time between onset of altered
mental status and start of appropriate specific therapy; e) neurologic outcomes at 1
year mRS score and extended Glasgow outcome scale (GOS); f) causes of death in
non-survivors at 1 year; g) quality of life and posttraumatic stress at 1 year: IADL and