The main purpose is to determine whether Triferic, administered orally with Shohl's solution,
is safe and effective for the treatment of iron-refractory iron-deficiency anemia (IRIDA).
Drug: Shohl's solution
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Full eligibility criteria for NCT02905981
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Adult patients have provided informed consent and have signed the informed consent form. For pediatric patients, parents/legal guardians of the patient have the ability to understand the requirements of the study and have demonstrated a willingness to have their child comply with all study procedures by signing the informed consent form. Where applicable, assent of the pediatric patient has also been obtained for all study procedures prior to any study-related activities.
Patient has a history of congenital hypochromic microcytic anemia.
Patient has a mean corpuscular volume (MCV) ≤75 fL at screening.
Patient has a serum transferrin saturation ≤15% at screening.
Patient has a history of no or incomplete response to oral iron therapy.
Patient has a history of no or incomplete response to intravenous iron administration.
Patient has a history of hepcidin concentration ≥10 ng/mL (3.58 nM) off iron supplements, adjusted for the specific hepcidin assay used to be at least 1 standard deviation (SD) greater than the mean for patients with iron-deficiency anemia.
Patient is documented to have homozygous or compound heterozygous pathogenic mutations in TMPRSS6 in a CLIA-certified laboratory.
Patient has appropriate laboratory values for their disease state at screening (per investigator judgment).
Patient has no significant abnormal findings on physical examination at screening that would preclude participation in the study (per investigator judgment).
If the patient is female, she must be pre-pubertal, have had documented surgical sterilization ≥2 years prior to screening, or be practicing adequate birth control. All female patients 9 years of age and older, and also any who have reached menarche before age 9 years, must have a negative serum pregnancy test during screening. It is the investigator's responsibility to determine whether the patient has adequate birth control for study participation.
Patient has had IV or oral iron supplements within 2 weeks prior to Visit 2.
Patient has had a blood transfusion within 3 months prior to Visit 2.
Patient is receiving intravenous or oral antibiotics or antifungals for any infectious process. Prophylactic antibiotics administered on a regular basis are allowed. Otherwise-eligible patients may be rescreened when they have recovered from any acute illnesses.
Patient has a body weight of <11 lbs (5 kg) at screening.
Patient has participated in an investigational drug study within the 30 days prior to Visit 2.
Patient has any condition that, in the opinion of the investigator, is likely to prevent the patient from complying with or successfully completing the protocol.
All locations for NCT02905981
View full eligibility
Tris trial is registered with FDA with number: NCT02905981. The sponsor of the trial is Rockwell Medical Technologies, Inc. and it is looking for 28 volunteers for the current phase.
Official trial title: Triferic (Ferric Pyrophosphate Citrate) Administered Orally With Shohl's Solution for the Treatment of Iron-Refractory Iron-Deficiency Anemia
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