The purpose of this study is to assess the safety and efficacy of adjuvanted R21 alone and in
combination with a viral-vectored vaccine regimen (constituting adjuvanted R21 + ChAd63 and
MVA encoding ME-TRAP) against malaria sporozoite challenge in healthy malaria-naive
Healthy adult volunteers will be recruited in London, Oxford and Southampton.
All vaccinations will be administered intramuscularly. The study involves having either two,
three or five vaccinations and then undergoing challenge infection with malaria, or receiving
no vaccinations then undergoing challenge infection with malaria.