Polypodium Leucotomos Extract (PLE) is a tropical fern that has antioxidative,
photoprotective, chemoprotective, anti-inflammatory, and immunomodulatory properties. The
antioxidative effects of PL include inhibition and scavenging of free radicals, lipid
peroxidation and reactive oxygen species (ROS) such hydrogen peroxide, superoxide anion,
hydroxyl radical and singlet oxygen. Visible light (400-700 nm) causes pigmentation in
melanocompetent individuals and induces DNA damage in the human skin through ROS production.
The goal of this study is to determine whether the administration of oral PLE has an effect
on the development of visible light induced pigmentation.