Objective: To compare the efficacy and safety of the misoprostol vaginal insert (MVI) with an
off-label use of oral misoprostol (OM).
Design: Pair-matched case-control study.
Setting: Tertiary-care academic centre in Germany.
Population: A cohort of 138 women ≥ 37/0 weeks pregnant undergoing labour induction.
Methods: The induction of labour with a retrievable prostaglandin vaginal insert in a
consecutive series of 69 women was compared with induction using oral misoprostol in a
Main outcome measures: The primary outcomes were the time from induction to delivery and the
caesarean section rate. Secondary outcomes included uterine tachysystole, tocolysis, fetal
scalp blood testing, meconium-stained amniotic fluid, umbilical arterial pH, and Apgar score.