Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the
pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the
pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery.
Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological
availability of medication. In this study we investigate the pharmacokinetic effects of
bariatric surgery on amlodipine.